GLP-1 medications like Wegovy may help support liver health in people with moderate to severe fibrosis, but success depends on the right guidance. Oshi GI providers guide you through medication options, monitor your liver health, and tailor your care plan to your needs.
A diagnosis of metabolic dysfunction-associated steatohepatitis (MASH) with fibrosis can feel like a lot to take in. You may already be doing the “right things,” like making dietary changes, staying active, taking medications, or following your provider’s other recommendations. Maybe you’re not seeing progress, or you’re not sure whether your efforts are making a difference for your liver health.
If you’re reading this, you may already know that MASH is a more advanced form of metabolic dysfunction-associated steatotic liver disease (MASLD) (aka fatty liver). It means there’s inflammation in the liver along with a buildup of fat. Fibrosis refers to early scarring that can develop when the liver is chronically stressed. At this stage, the goal of care is to protect your liver and slow disease progression.
At Oshi Health, your gastrointestinal (GI) care team can work with you to figure out whether medications like GLP-1s like Ozempic or Zepbound might fit into your comprehensive treatment plan.
GLP-1s and MASH care
GLP-1s like Mounjaro and Ozempic are increasingly playing a role in treating MASH. In 2025, the U.S. Food and Drug Administration approved the brand-name drug Wegovy as a treatment for MASH with moderate to severe liver fibrosis.
You might have heard of these medications for diabetes or weight management, but when used to treat MASH, the focus isn’t on changing your body size. It’s about supporting the liver at the metabolic level.
GLP-1s act on some of the underlying metabolic processes associated with MASH. They can influence how the body processes sugar and fat, and may help address the inflammation and fat buildup that can negatively impact liver health.
In a phase 3 clinical trial of the GLP-1 semaglutide in people with MASH and moderate to severe fibrosis, participants experienced improvements in liver health, with more than one-third showing a reduction in fibrosis.
Navigating GLP-1 side effects
It’s normal to worry about side effects like nausea and GI symptoms with GLP-1s. Your Oshi care team can support you along the way and help you manage potential side effects, which are usually mild. Potential GLP-1 side effects include:
- Nausea
- Appetite changes
- Digestion changes
- Reflux
- Gallbladder disease
- Changes in energy levels
How Oshi supports patients using GLP-1s for MASH with fibrosis
GI care
Your GI provider can determine whether a GLP-1 medication like Wegovy is right for you based on your liver health, symptoms, and medical history. With Oshi, getting the testing you need is simple. Your provider can order labs to keep an eye on your liver health and treatment progress, and our care coordinators will help you find a convenient, in-network location near you. You’ll be able to easily view your results and talk through what they mean with your provider. From there, your care team will work closely with you to adjust your plan as needed, based on your results and any potential side effects.
Dietary care
GLP-1 medications can change your appetite and how your body responds to food. An Oshi registered dietitian can help you maintain a balanced diet and make sure you’re eating enough, even when your appetite shifts. They’re also equipped to support you with common GLP-1-related digestive side effects like nausea, early fullness, and GI discomfort.
Gut-brain support
Changes in your appetite, routines, or symptoms can feel stressful. A gut-brain specialist can help you navigate those adjustments so you can stay consistent with your treatment plan. They’ll also help you manage related challenges like fatigue (which happens for some people, especially after injection day) or anxiety (about your condition or taking an injectable medication).
Is Oshi the right fit for you?
You might benefit from Oshi’s coordinated approach if you:
- Have MASH with fibrosis and want guidance that goes beyond medication alone
- Are looking for liver-focused care that doesn’t center on weight loss or place blame on you
- Want a care team to address your liver health and digestive health, not just a prescription
Your expert liver care team
From diagnosis to ongoing management, our GI specialists are here to support your liver health.
Takeaway
MASH with moderate to severe fibrosis is a serious diagnosis, but it’s not something you have to manage alone. GLP-1s like Wegovy and Ozempic can be a helpful treatment tool when paired with the right support. An integrated team of GI experts, including registered dietitians and gut-brain specialists, can make treatment feel more manageable and less overwhelming.
Oshi is your partner in expert liver care
Liver conditions like metabolic dysfunction-associated steatohepatitis (MASH) can be hard to manage on your own without clear guidance.
Oshi Health gives you access to GI providers, registered dietitians, and gut-brain experts who specialize in liver health. They can evaluate your symptoms, order labs, and create a personalized care plan based on your needs.
Plus, with convenient virtual visits, our specialists can monitor your progress over time and adjust your plan based on your lab results and how you’re feeling.
You deserve clear answers and expert care for your liver health.
